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Trelegy Ellipta

FLUTICASONE FUROATE, UMECLIDINIUM BROMIDE AND VILANTEROL TRIFENATATE - GlaxoSmithKline LLC

is a combination of fluticasone furoate, an inhaled corticosteroid (ICS); umeclidinium, an anticholinergic; and vilanterol, a long-acting beta 2 -adrenergic agonist (LABA), indicated for: • the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). • the maintenance treatment of asthma in patients aged 18 years and older.

Label facts

Application
NDA209482
Route
RESPIRATORY (INHALATION)
Label updated
June 2, 2023

Indication

is a combination of fluticasone furoate, an inhaled corticosteroid (ICS); umeclidinium, an anticholinergic; and vilanterol, a long-acting beta 2 -adrenergic agonist (LABA), indicated for: • the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). • the maintenance treatment of asthma in patients aged 18 years and older.

Dose and administration

• For oral inhalation only. • Maintenance treatment of COPD: 1 actuation of TRELEGY ELLIPTA 100/62. 5/25 mcg once daily administered by oral inhalation.

Side effects

  • upper respiratory tract infection
  • pneumonia
  • bronchitis
  • oral candidiasis
  • headache
  • back pain
  • arthralgia
  • influenza

Safety flags

Three trials included adult and adolescent subjects aged 12 years and older

Contraindication: is contraindicated in the following conditions: • Primary treatment of status asthmaticus

Contraindication: other acute episodes of COPD

Contraindication: asthma where intensive measures are required .

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